Chinese Journal of Magnetic Resonance >
Design and Evaluation of an Olfactometer for fMRI Studies
Received date: 2013-11-11
Revised date: 2014-10-28
Online published: 2014-12-05
Supported by
中科院科研装备研制资助项目(YZ201253)，苏州市科技资助项目(SYG201125).
We developed a computer-controlled olfactometer for delivering odors for functional magnetic resonance imaging (fMRI) experiments. The olfactometer is consisted of an air transport system and a control system. Odors are produced and delivered by the air transport system, in which air flow first passes through liquid mixed with odorants in gas-washing bottles and then is delivered to the test subjects. The control system provides a user interface for
operating the device and controlling solenoid valves. The system is based on virtual instrumentation technology, and the software for it is written in LabVIEW. The device was tested on a Siemens 3.0 T MRI scanner. Block-design fMRI data were collected from one healthy subject who was stimulated with two odors, isoamyl acetate and pyridine. The raw fMRI data were processed with Matlab-based SPM8 and MarsBaR toolbox. Region-of-interest (ROI)-based analysis was performed for the left orbitofrontal cortex and left insula. It was found that the signal changes in the two ROIs were basically in compliance with the stimulation paradigm, but the signal changes induced by pyridine were more robust than that produced by isoamyl acetate stimulation. In the same ROI, the signal intensity changes caused by pyridine were higher than that induced by isoamyl acetate.
Key words： fMRI; olfactometer; olfactory; stimulation
WANG Xiao-guan1–3 , YANG Xiao-dong3* , WANG Hui3 , CHANG Yan3 , XU Ya-jie3 , ZHANG Guang-cai3 , JIANG Rui-rui1–3 . Design and Evaluation of an Olfactometer for fMRI Studies[J]. Chinese Journal of Magnetic Resonance, 2014 , 31(4) : 477 -487 . DOI: 10.11938/cjmr20140403
[1] Yang Li-qin(杨丽琴), Lin Fu-chun(林富春), Lei Hao(雷皓). Resting state functional connectivity in brain studied by fMRI approach(静息状态下脑功能连接的磁共振成像研究)[J]. Chinese J Magn Reson(波谱学杂志), 2010, 27(3): 326－340．
[2] Hsieh Chang-wei(谢长倭), Wu Jih-huah(吴季华), Hsieh Chao-hsien(谢昭贤), et al. The preliminary fMRI investigation of 10 Hz modulation laser acupuncture induced cerebral cortical activation in human(以功能性核磁共振造影初探10 Hz 调制激光针灸刺激所引发人类大脑皮质的活化现象)[J]. Chinese J Magn Reson(波谱学杂志), 2010, 27(3): 369－378．
[3] Wang J, Eslinger P J, Doty R L, et al. Olfactory deficit detected by fMRI in early Alzheimer's disease[J]. Brain Research, 2010, 1357: 184－194．
[4] Moessnang C, Frank G, Bogdahn U, et al. Altered activation patterns within the olfactory network in Parkinson's disease[J]. Cereb Cortex, 2011, 21(6): 1 246－1 253．
[5] Johnson B N, Sobel N. Methods for building an olfactometer with known concentration outcomes[J]. J Neurosci Methods, 2007, 160(2): 231－245．
[6] Lundstrom J N, Gordon A R, Alden E C, et al. Methods for building an inexpensive computer-controlled olfactometer for temporally-precise experiments[J]. Int J Psychophysiol, 2010, 78(2): 179－189.
[7] Cuevas I, Gerard B, Plazxa P, et al. Development of a fully automated system for delivering odors in an MRI environment[J]. Behav Res Methods, 2010, 42(4): 1 072－1 078.
[8] Liu Jian-feng(刘剑锋). Development of a Computer-controlled Olfactometer for Electrophysiological and fMRI Studies of Olfaction, and Studies of Olfactory Event-related Potentials and Olfactory Event-related Founctional Magnetic Resonance Imaging in Human(OEP-98C 型嗅觉诱发电位仪的研制及人嗅觉事件相关电位和嗅觉事件相关功能磁共振研究)[D].
Beijing(北京): Chinese Academy of Medical Sciences (中国协和医科大学), 2005.
[9] You Hui(有慧). Study on Structural and Functional MR imaging of the olfactory system(嗅觉系统结构和功能MR成像研究)[D]. Beijing(北京): Chinese Academy of Medical Sciences(中国协和医科大学), 2007.
[10] You Hui(有慧), Wang Jian(王剑), Liu Jian-feng(刘剑锋), et al. Olfactory functional magnetic resonance imaging with modified OEP-98C olfactometer and event-related design(应用OEP-98C 型嗅觉诱发电位仪进行事件相关设计嗅觉功能磁共振成像)[J]. Acta Acad Med Sin (中国医学科学院学报), 2009, 31(2): 134－138.
[11] Sommer J U, Maboshe W, Griebe M, et al. A mobile olfactometer for fMRI-studies[J]. J Neurosci Meth, 2012, 209(1): 189－194.
[12] Wang Xiao-guan(王骁冠), Zhu Zhen-wei(祝祯伟), Yang Xiao-dong(杨晓冬), et al. Advances in automatic stimulation devices for functional magnetic resonance imaging(功能磁共振成像自动刺激装置研究进展)[J]. China Medical Devices(中国医疗设备), 2013, 28(1): 1－8.
[13] Yang Hong-tao(杨洪涛), Zhang Wei(张炜), Zhang Jing(张晶), et al. Design on high precision control system of electromagnetic valve based on LabVIEW(基于LabVIEW 的高精度电磁阀控制系统设计)[J]. Tool Engineering(工具技术), 2012, 46(1): 31－34.
[14] Yang Gao-ke(杨高科). Development and Management of LabVIEW Virtual Instrument Project (LabVIEW 虚拟仪器项目开发与管理)[M]. Beijing(北京): China Machine Press(机械工业出版社), 2012.
[15] Wu Jian-lin(伍建林), Zhang Qing(张清), Zhang Jing-wen(张竞文), et al. Functional MRI study on regional brain responses to pleasant and unpleasant odors(愉快及非愉快气体激活相应脑区的功能磁共振成像实验研究)[J]. Chinese Journal of Medical Imaging Technology(中国医学影像技术), 2006, 22(1): 2－6.
[16] Ni Ming-fei(倪鸣飞), Wu Jian-lin(伍建林), Zhang Qing(张清), et al. Functional MRI research of smoker’s responses to smoking olfactory cue(功能磁共振成像观察吸烟成瘾者对香烟的嗅觉诱导反应)[J]. Chinese Journal of Medical Imaging Technology(中国医学影像技术), 2010, 26(2): 238－242.
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