Chinese Journal of Magnetic Resonance >
Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by 31P NMR
Received date: 2014-05-19
Revised date: 2015-01-11
Online published: 2015-03-05
In this paper, we report the use of 31P NMR to monitor the synthesis process of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). 31P NMR was used to detect signals from the residues of key intermediates phosphorous acid and 3. The synthesis process was optimized based on the 31P NMR results. Impurity such as PCl3 were analyzed.
Key words： 31P NMR; HEDP; process optimization
SHI Bo , DU Cheng-tang* , ZHUANG Dong-qing . Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by 31P NMR[J]. Chinese Journal of Magnetic Resonance, 2015 , 32(1) : 116 -122 . DOI: 10.11938/cjmr20150113
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