Chinese Journal of Magnetic Resonance >
“Double Edge” Effects of Nitric Oxide Free Radical in Cardio-Brain-Vascular Diseases and Health Studied by ESR
Received date: 2015-04-22
Revised date: 2015-05-12
Online published: 2015-06-05
Nitric oxide (NO) is a simple gas with free radical properties. It appears as a major signaling molecule in cardiovascular, immune and nervous systems. NO is generated by three isoforms of NO synthase, endothelial NO synthase (eNOS), neuronal NO synthase (nNOS) and inducible NO synthase (iNOS) in different cells. It is known that NO is an important physiological molecule in the regulation of blood pressure, vascular tone, however, excessive NO produced by iNOS results in inhibition of cardiac contractility, impairment of mitochondrial respiration and apoptosis. NO has been shown to influence neurotransmitter release and synaptogenetic processes, modulate the synaptic plasticity, indicating that NO plays an important role in the development, maintenance and regulation of brain circuits, as signaling molecule in mammary and learning. Increasing evidences indicate that excessive NO may damage cardiovascular and neurons and even cause cardiovascular and neurodegenerative diseases. We review the results about the “double edge” effects of NO in cardio-brain-vascular health and diseases and the protective effects of antioxidants in recent years studied by ESR.
ZHAO Bao-lu . “Double Edge” Effects of Nitric Oxide Free Radical in Cardio-Brain-Vascular Diseases and Health Studied by ESR[J]. Chinese Journal of Magnetic Resonance, 2015 , 32(2) : 195 -207 . DOI: 10.11938/cjmr20150205
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