Chinese Journal of Magnetic Resonance >
Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI
Received date: 2015-02-11
Revised date: 2015-05-10
Online published: 2015-06-05
Supported by
Gants from the National Natural Science Foundation of China (81227902) and the Chinese Academy of Sciences (KJCX2-EW-N06-04).
Hyperpolarized 3He or 129Xe diffusion MRI has been demonstrated as a promising technique for the detection of microanatomical changes in chronic obstructive pulmonary disease (COPD). Compared with 3He, 129Xe is more available for the potential clinical applications. However, the measurement of 129Xe apparent diffusion coefficient (ADC) possesses more challenges due to the relevant low gyromagnetic ratio and spin polarization. In this present study, a single b value (b = 14 s/cm2) diffusion-weighted hyperpolarized 129Xe MRI sequence was used to image a balloon phantom, healthy rats, and the COPD rats, respectively. All COPD rats were induced by second-hand smoke and lipopolysaccharide (LPS). The lung 129Xe ADC maps were obtained on a 7 T MRI scanner. The mean lung parenchymal 129Xe ADCs were 0.044 22±0.002 9 and 0.042 34±0.002 3 cm2/s (Δ = 0.8/1.2 ms) for the COPD rats, which showed significant increasements in comparison with healthy ones (0.037 7±0.002 3 and 0.036 7±0.001 3 cm2/s). Furthermore, the corresponding ADC histogram of the COPD rats exhibited a broader distribution as compared with the healthy ones. Our experiments demonstrated that the alveolar airspace
enlargement in the COPD rats are able to be quantitatively evaluated by hyperpolarized xenon diffusion-weighted MRI.
Key words： hyperpolarized xenon; MRI; lung; ADC; COPD
RUAN Wei-wei1 , 2 , ZHONG Jian-ping1 , HAN Ye-qing1 , SUN Xian-ping1 , YE Chao-hui1 , ZHOU Xin1* . Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI[J]. Chinese Journal of Magnetic Resonance, 2015 , 32(2) : 261 -272 . DOI: 10.11938/cjmr20150209
[1] Rabe K F, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease - GOLD executive summary[J]. Am J Resp Crit Care Med, 2007, 176(6): 532－555.
[2] Wang C B, Mugler J P, de Lange E E, et al. Lung injury induced by secondhand smoke exposure detected with hyperpolarized helium-3 diffusion MR[J]. J Magn Reson Imaging, 2014, 39(1): 77－84.
[3] Plotkowiak M, Burrowes K, Wolber J, et al. Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry[J]. Philos T Roy Soc A, 2009, 367(1 896): 2 347－2 369.
[4] Thurlbeck W M. Overview of the pathology of pulmonary-emphysema in the human[J]. Clin Lab Med, 1984, 4(3): 539－559.
[5] Yablonskiy D A, Sukstanskii A L, Quirk J D, et al. Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results[J]. Magn Reson Med, 2014, 71(2): 486－505.
[6] Driehuys B, Cofer G P, Pollaro J, et al. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI[J]. Proc Natl Acad Sci USA, 2006, 103(48): 18 278－18 283.
[7] Albert M S, Cates G D, Driehuys B, et al. Biological magnetic-resonance-imaging using laser polarized 129Xe[J]. Nature, 1994, 370(6 486): 199－201.
[8] Li H D, Zhang Z Y, Han Y Q, et al. Lung MRI using hyperpolarized gases[J]. Chinese J Magn Reson, 2014, 31(3): 307－320.
[9] Mata J, Altes T, Truwit J, et al. Characterization and detection of physiologic lung changes before and after placement of bronchial valves using hyperpolarized 3He MR imaging: preliminary study[J]. Acad Radiol, 2011, 18(9): 1 195－1 199.
[10] Moller H E, Chen X J, Saam B, et al. MRI of the lungs using hyperpolarized noble gases[J]. Magn Reson Med, 2002, 47(6): 1 029－1 051.
[11] Yablonskiy D A, Sukstanskii A L, Leawoods J C, et al. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI[J]. Proc Natl Acad Sci USA, 2002, 99(5): 3 111－3 116.
[12] Habib D, Grebenkov D, and Guillot G, et al. Gas diffusion in a pulmonary acinus model: experiments with hyperpolarized helium-3[J]. Magn Reson Imaging, 2008, 26(8): 1 101－1 113.
[13] Kaushik S S, Cleveland Z I, Cofer G P, et al. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease[J]. Magn Reson Med, 2011, 65(4): 1 155－1 165.
[14] Kirby M, Svenningsen S, Kanhere N, et al. Pulmonary ventilation visualized using hyperpolarized 3He and 129Xe magnetic resonance imaging: differences in COPD and relationship to emphysema[J]. J Appl Phys, 2013, 114(6): 707－715.
[15] Boudreau M, Xu X, Santyr G E, et al. Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema[J]. Magn Reson Med, 2013, 69(1): 211－220.
[16] Zhou X, Mazzanti M L, Chen J J, et al. Reinvestigating hyperpolarized relaxation time in the rat brain 129Xe longitudinal with noise considerations[J]. NMR Biomed, 2008, 21(3): 217－225.
[17] Li S W, Zhang L, Li C L, et al. Fumigation and intratracheal instillation of lipopolysaccharide or they combining ozone exposure for establishing COPD models in rats[J]. J Beijing Univ Tradit Chin Med, 2014, 37(5): 321－324.
[18] Mattiello J, Basser P J, Lebihan D, et al. Analytical expressions for the b-matrix in NMR diffusion imaging and spectroscopy[J]. J Magn Reson Ser A, 1994, 111(2): 232－232.
[19] Blackberg L, Metsanurk E, Tamm A, et al. Molecular dynamics study of xenon on an amorphous Al2O3 surface[J]. Nuclear Instrum Methods Phys Res Sect A, 2014, 759: 10－15.
[20] Chen X J, Moller H E, Chawla M S, et al. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient[J]. Magn Reson Med, 1999, 42(4): 721－728.
[21] Ouriadov A, Farag A, Kirby M, et al. Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease[J]. Magn Reson Med, 2013, 70(6): 1 699－1 706.
[22] Carrero-Gonzalez L, Kaulisch T, Ruiz-Cabello J, et al. Apparent diffusion coefficient of hyperpolarized 3He with minimal influence of the residual gas in small animals[J]. NMR Biomed, 2012, 25(9): 1 026－1 032.
[23] Halaweish A F, Hoffman E A, Thedens D R, et al. Effect of lung inflation level on hyperpolarized He apparent Diffusion coefficient Measurements in never-smokers[J]. Radialogy, 2012, 268(2): 572－580.
[24] Diaz S, Casselbrant I, Piitulainen E, et al. Validity of apparent diffusion coefficient hyperpolarized 3He MRI using MSCT and pulmonary function tests as references[J]. Eur J Radiol, 2009, 71(2): 257－263.
[25] Patz S, Muradyan I, Hrovat M I, et al. Diffusion of hyperpolarized 129Xe in the lung: a simplified model of 129Xe septal uptake and experimental results[J]. New J Phys, 2011, 13(1): 015009.
[26] Sukstanskii A L, Yablonskiy D A. Lung morphometry with hyperpolarized 129Xe: theoretical background[J]. Magn Reson Med, 2012, 67(3): 856－866.
[27] Kirby M, Svenningsen S, Owrangi A, et al. Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease[J]. Radiology, 2012, 265(2): 600－610.
[28] Nouls J, Fanarjian M, Hedlund L, et al. A constant-volume ventilator and gas recapture system for hyperpolarized gas MRI of mouse and rat lungs[J]. Concepts Magn Reson Part B Magn Reson Eng, 2011, 39B(2): 78－88.
[29] Shukla Y, Wheatley A, Kirby M, et al. Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease[J]. Acad Radiol, 2012, 19(8): 941－951.
[30] Fricker M, Deane A, Hansbro P M, et al. Animal models of chronic obstructive pulmonary disease[J]. Expert Opin Drug Dis, 2014, 9(6): 629－645.
[31] Gierada D S, Woods J C, Bierhals A J, et al. Effects of diffusion time on short-range hyperpolarized 3He diffusivity measurements in emphysema[J]. J Magn Reson Imaging, 2009, 30(4): 801－808.
/
| 〈 |
|
〉 |