Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T

ZHANG Miao1; LU Jian-hua2; CAI Cong-bo3; CAI Shu-hui1*

doi:10.11938/cjmr20150406

Chinese Journal of Magnetic Resonance >

2015 , Vol. 32 >Issue 4: 606 - 617

DOI: https://doi.org/10.11938/cjmr20150406

Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T

ZHANG Miao1 ,
LU Jian-hua2 ,
CAI Cong-bo3 ,
CAI Shu-hui1*

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1. Department of Electronic Science, Xiamen University, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen 361005, China;
2. Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803, USA;
3. Department of Communication Engineering, Xiamen University, Xiamen 361005, China

*Corresponding author： CAI Shu-hui, Tel: +86-592-2183301, E-mail: shcai@xmu.edu.cn.

Received date: 2015-02-04

Revised date: 2015-10-25

Online published: 2015-12-05

Supported by

国家自然科学基金资助项目(U1232212, 81171331)，高等学校博士学科点专项科研基金资助项目(20130121110014)

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Abstract

When performing chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) on biological samples at high fields, nuclear Overhauser enhancement (NOE) effects may produce negative signals on the Z-spectra. The NOE-related signal intensity changes have the potential to become a new contrast mechanism. However, the presence of lipids signals within the same chemical shift range may affect the observation of true NOE effect-related signal changes. In this work, we first analyzed the influence of lipid signals on the NOE effects in tissues abundant in lipid via experiments on eggs. Similar experiments were then carried out on healthy rats and rats with brain tumors. The results showed that the presence of large lipid signals could cause pseudo NOE effects and degrade the accuracy of NOE contrast imaging.

Key words： magnetic resonance imaging(MRI); NOE contrast; Lorentzian fitting; fat saturation

Cite this article

ZHANG Miao1 , LU Jian-hua2 , CAI Cong-bo3 , CAI Shu-hui1* . Effects of Lipids Signals on Nuclear Overhauser Enhancement Contrast Imaging at 7 T
[J]. Chinese Journal of Magnetic Resonance, 2015 , 32(4) : 606 -617 . DOI: 10.11938/cjmr20150406

References

[1] Ward K, Aletras A, Balaban R, et al. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)[J]. J Magn Reson, 2000, 143(1): 79－87.

[2] Zhou J, Van Zijl P C. Chemical exchange saturation transfer imaging and spectroscopy[J]. Prog Nucl Magn Reson Spectrosc, 2006, 48(2-3): 109－136.

[3] Sherry A D, Woods M. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging[J]. Annu Rev Biomed Eng, 2008, 10: 391－411.

[4] Vinogradov E, Sherry A D, Lenkinski R E, et al. CEST: From basic principles to applications, challenges and opportunities[J]. J Magn Reson, 2013, 229: 155－172.

[5] Kogan F, Hariharan H, Reddy R, et al. Chemical exchange saturation transfer (CEST) imaging: Description of technique and potential clinical applications[J]. Curr Radiol Rep, 2013, 1(2): 102－114.

[6] Solomon I. Relaxation processes in a system of two spins[J]. Phys Rev, 1955, 99(2): 559－565.

[7] Jin T, Wang P, Zong X, et al. MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear Overhauser effect at 9.4 T[J]. Magn Reson Med, 2013, 69(3): 760－770.

[8] Ling W, Regatte R R, Navon G, et al. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)[J]. Proc Natl Acad Sci USA, 2008, 105(7): 2 266－2 270.

[9] Jones C K, Huang A, Xu J, et al. Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7 T[J]. NeuroImage, 2013, 77: 114－124.

[10] Cai K, Haris M, Singh A, et al. Magnetic resonance imaging of glutamate [J]. Nat Med, 2012, 18(2): 302－306.

[11] Hua J, Jones C K, Blakeley J, et al. Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain[J]. Magn Reson Med, 2007, 58(4): 786－793.

[12] Van Zijl P C, Zhou J, Mori N, et al. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids[J]. Magn Reson Med, 2003, 49(3): 440－449.

[13] Zhou J, Blakeley J O, Hua J, et al. Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging[J]. Magn Reson Med, 2008, 60(4): 842－849.

[14] Zhou J, Hong X, Zhao X, et al. APT-weighted and NOE-weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses[J]. Magn Reson Med, 2013, 70(2): 320－327.

[15] Mougin O E, Coxon R C, Pitiot A, et al. Magnetization transfer phenomenon in the human brain at 7 T[J]. NeuroImage, 2010, 49(1): 272－281.

[16] Liu D, Zhou J, Xue R, Zuo Z, et al. Quantitative characterization of nuclear Overhauser enhancement and amide proton transfer effects in the human brain at 7 T[J]. Magn Reson Med, 2013, 70(4): 1 070－1 081.

[17] Zaiss M, Kunz P, Goerke S, et al. MR imaging of protein folding in vitro employing Nuclear-Overhauser-mediated saturation transfer[J]. NMR Biomed, 2013, 26(12): 1 815－1 822.

[18] Behar K L, Rothman D L, Spencer D D, et al. Analysis of macromolecule resonances in ¹H NMR spectra of human brain[J]. Magn Reson Med, 1994, 32(3): 294－302.

[19] Lu J, Zhou J, Cai C, et al. Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression[J]. Magn Reson Med, 2014, doi:10.1002/mrm.25277.

[20] Jones C K, Polders D, Hua J, et al. In vivo three-dimensional whole-brain pulsed steady state chemical exchange saturation transfer at 7 T[J]. Magn Reson Med, 2012, 67(6): 1 579－1 589.

[21] Dewey B. Simulation and Optimization of Pulsed Chemical Exchange Saturation Transfer for Clinical Application at 3 T [D]. Nashville, Tennessee, USA: Vanderbilt University, 2013.

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