Chinese Journal of Magnetic Resonance >
A 1H NMR-Based Metabonomic Study on the Serum of Haematitum-Treated Rats
Received date: 2014-12-04
Revised date: 2015-10-23
Online published: 2015-12-05
Supported by
国家自然科学基金资助项目(20975097, 21305134)
Wistar rats were intragastrically administered with different doses (0, 2, 5 g/kg body weight) of haematitum. 1H NMR-based metabonomic techniques were used to analyze the metabolic profiles of the serum samples collected from the treated rats. Significant treatment-related changes were observed for the levels of β-hydroxybutyate, acetate, acetone, choline, glycerophosphorylcholine, glucose, lactate, low density lipoprotein, very low density lipoprotein and lipids. Such biochemical changes indicated that haematitum treatment at the dose of 2 or 5 g/kg body weight gave rise to reactive oxygen species (ROS) and caused peroxidation damage. It is concluded that haematitum treatment affects glucose, lipid and energy metabolism in rats.
WEI Ying1 , 2 , ZHANG Wen-jun1 , XUE Rong2 , LI Xiao-jing2* , PEI Feng-kui2 . A 1H NMR-Based Metabonomic Study on the Serum of Haematitum-Treated Rats[J]. Chinese Journal of Magnetic Resonance, 2015 , 32(4) : 628 -636 . DOI: 10.11938/cjmr20150408
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