Chinese Journal of Magnetic Resonance >
An NMR Spectroscopy Study on Peptidomimetics Cyclo[-RGD-ψ(triazole)-GD-]
Received date: 2015-03-27
Revised date: 2016-04-08
Online published: 2016-06-05
The spectral data of peptidomimetics cyclo[-RGD-ψ(triazole)-GD-] were reported, including UV, FT-IR and NMR (i.e., 1H NMR, 1H-1H COSY, 13C NMR, DEPT, 1H-13C HSQC and 1H-13C HMBC). The NMR signals were assigned. The infrared spectrum was analyzed to derive the types of vibrations of the functional groups in the compound. The molecular structure of peptidomimetics cyclo[-RGD-ψ(triazole)-GD-] was determined.
Key words: peptidomimetics; NMR; assignment; chemical shift; structural elucidation
LIU Ya-qin , HE Ling , YU Ming-xin . An NMR Spectroscopy Study on Peptidomimetics Cyclo[-RGD-ψ(triazole)-GD-][J]. Chinese Journal of Magnetic Resonance, 2016 , 33(2) : 337 -344 . DOI: 10.11938/cjmr20160215
[1] Pierschbacher M D, Ruoslahti E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule[J]. Nature, 1984, 309(5963):30-33.
[2] Kovacs Z, De Leon-Rodriguez L M. Conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic Acid (DOTA) and its terivatives to peptides:synthesis,applications and future prospects[J]. Mini-Rev Org Chem, 2007, 4(4):281-291.
[3] Wermuth J L. Goodman S, Jonczyk A, et al. Stereoisomerism and biological activity of the selective and superactive αvβ3 integrin inhibitor cyclo(-RGDfV-) and its retro-inverso peptide[J]. J Am Chem Soc, 1997, 119(6):1328-1335.
[4] Rerat V, Dive G, Cordi A A, et al. Alpha v beta 3 integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers[J]. J Med Chem, 2009, 52(22):7029-7043.
[5] Wu Chun-li(吴春丽), Li Jie-ming(李杰明), Wei Hui-jie(魏会杰), et al. Spectral analysis and structural elucidation of atorvastatin lactone (阿托伐他汀内酯的波谱学数据与结构确证)[J]. Chinese J Magn Reson(波谱学杂志), 2014, 31(2):268-277.
[6] Yuan Yun-fei(袁云飞), Hong Hai(洪海), Yang Xiao-yun(杨晓云), et al. Spectroscopic data of fluacrypyrim and interpretations(嘧螨酯波谱学数据全归属)[J]. Chinese J Magn Reson(波谱学杂志), 2013, 30(4):567-575.
[7] Liu Y Q, Zhang L H, Wan J P, et al. Design and synthesis of cyclo[-Arg-Gly-Asp-Ψ(triazole)-Gly-Xaa-] peptide analogues by click chemistry[J]. Tetrahedron, 2008, 64(47):10728-10734.
[8] Liu X G, Yan X M, Mo W, et al. 1H NMR assignment and secondary structure of recombinant RGD-hirudin[J]. Magn Reson Chem, 2005, 43(11):956-961.
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