靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展
胡晓东,蓝文贤,王春喜,曹春阳*(
)
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Research Advance and NMR Studies of Anti-Cancer Small Molecules Targeting c-MYC G4-DNA
Xiao-dong HU,Wen-xian LAN,Chun-xi WANG,Chun-yang CAO*()
)
图6. 四种配体与G4-DNA的结合模型.(a)配体在5’端、3’端或两端叠加的复合物结构模型；(b)配体插入G-四集体之间的结构模型；(c)配体在沟槽或loop上结合的结构模型；(d)配体停留在G4-DNA结构中心的复合物结构模型
Fig.6. Four binding models of the ligands with G4-DNA. (a) Ligands stack to the 5'-end, 3'-end, or both termini; (b) Ligands insert into G-tetrads; (c) Ligands bind to the groove and loop regions; (d) Ligands stay in the center of G4 structure
