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非天然氨基酸在蛋白质动态特性核磁共振研究中的应用
史朝为,石攀,田长麟*()
NMR Studies of Large Protein Dynamics Using Unnatural Amino Acids
Chao-wei SHI,Pan SHI,Chang-lin TIAN*()

图2. 一维19F NMR数据显示(a)组蛋白H3末端诱导DNMT3A蛋白发生构象变化[33]，(b) MLL3SET受RBBP5-ASH2L激活引起构象变化[34]，以及(c) Nedd4家族E3链接酶Itch自抑制激活机制[35]

Fig.2. 1D 19F NMR spectra were used for investigation of (a) DNMT3A conformation change on histone H3 binding[33], (b) MLL3SET conformation change activated by RBBP5-ASH2L[34], and (c) the Nedd4 family E3 ligase Itch auto-inhibition and activation[35]