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T69E模拟磷酸化修饰对Bcl-2与Nur77相互作用的影响
徐倩1,2,陈朗1,2,胡翔颖1,李从刚1,刘乙祥1,*(),姜凌1,*()
The Effect of T69E-mimicked Phosphorylation on the Interaction Between Bcl-2 and Nur77
Qian XU1,2,Lang CHEN1,2,Xiang-ying HU1,Cong-gang LI1,Yi-xiang LIU1,*(),Ling JIANG1,*()

图4. T69E突变体的功能验证.(a) 野生型胞内全长Bcl-2（wtBcl-2，蓝色）及其T69E突变体（红色）的15N-1H TROSY谱图比较；(b) Nur77 LBD（wtNur77）滴定T69E突变体的15N-1H TROSY谱图

Fig.4. Functional validation of T69E mutant. (a) 15N-1H TROSY spectra of wtBcl-2 (blue) and T69E mutant (red); (b) 15N-1H TROSY spectra of T69E mutant titrated with wtNur77