定量NMR中多种检出限评估方法的比较

陈雷,刘红兵,刘惠丽

Comparison of Different Approaches for Estimation of the Detection Limit of Quantitative NMR

Lei CHEN,Hong-bing LIU,Hui-li LIU

表4 不同评估方法计算得到的检出限

Table 4 Limits of detection determined with different approaches

方法 计算公式 检出限/(μmol/L) 校准曲线法 ${X_D} = \frac{{\delta (\nu , \alpha , \beta ) \cdot {S_{y/x}}}}{b} \cdot \sqrt {1 + \frac{1}{{I \times J}} + \frac{{{{\bar x}^2}}}{{J\sum\nolimits_{i = 1}^I {{{({x_i} - \bar x)}^2}} }}} $ 14.4 校准方程参数法 ${X_D} = 3{S_{y/x}}/b$ 10.4 数学模型法 ${X_D} = ({k_1} + {k_2}) \cdot \bar s/b$ 14.1 信噪比回归曲线法 ${X_D} = 3{S_{y/x - SN}}/{b_{SN}}$ 14.3 EPA法 ${X_D} = {t_{(1 - \alpha , {v_1} + {v_2})}}{S_{{\rm{pooled}}}}$ 6.2