阿卡波糖的核磁共振数据解析

李玉江, 赵伟, 陶乐, 路博华, 郑果, 张海艳, 郭晓河, 赵天增

NMR Data Analysis of Acarbose

LI Yujiang, ZHAO Wei, TAO Le, LU Bohua, ZHENG Guo, ZHANG Haiyan, GUO Xiaohe, ZHAO Tianzeng

表2 阿卡波糖的¹³C NMR数据（DMSO-d₆，400 MHz）

Table 2 ¹³C NMR data of acarbose (DMSO-d₆, 400 MHz)

原子编号		δ_C	DEPT	HSQC	HMBC(δ_H)	文献[12][δ_C, D₂O]
A	1	56.0	CH	3.28	H-2,3, OH-2, H-7	A	58.7
	2	70.8	CH	3.38	H-3, OH-4, OH-3, OH-2, H-7		75.2
	3	72.5	CH	3.58	H-1, H-4, OH-4, OH-3, OH-2		75.2
	4	71.2	CH	3.66	H-3, H-6, OH-4, OH-3, OH-2, H-7		74.1
	5	140.3	C		H-3, H-4, H-6, OH-4, OH-6, H-7		143.2
	6	61.3	CH₂	3.94	H-4, OH-6, H-7		64.1
	7	121.4	CH	5.59	H-4, H-6		124.3
B	1'	101.1	CH	4.92	H-2', 3', OH-2'	B	102.5
	2'	72.0	CH	3.28	OH-2', OH-3'		73.8
	3'	73.7	CH	3.28	H-4', H-2', H-1', OH-2', NH, OH-3'		75.7
	4'	64.9	CH	2.13	H-6', H-2', 3', H-5', NH, OH-3'		67.1
	5'	69.5	CH	3.58	H-6', H-4', H-1'		72.5
	6'	18.3	CH₃	1.16	H-5'		20.0
Cα	1''	100.5	CH	5.00	H-2'', 3'', 5'', OH-2''	C	102.3
	2''	71.9	CH	3.28	H-3'', 4'', H-1'', OH-3'', OH-2''		74.5
	3''	72.8	CH	3.28	H-2'', 4'', 5'', H-1'', OH-3'', OH-2''		75.9
	4''	79.6^*	CH	3.28	H-6''α, H-6''β		79.7
	5''	73.3	CH	3.28	H-3'', 4'', H-6''β, OH-6''		74.0
	6''	60.3	CH₂	3.58, 3.66	H-4'',OH-5'',OH-6''		63.1
Cβ	1'''	100.5	CH	5.00	H-2''', 5''', OH-2'''
	2'''	71.9	CH	3.28	H-4''', OH-3''', H-1''', OH-2'''
	3'''	72.1	CH	3.58	H-2''', 4''', OH-3''', OH-2'''
	4'''	79.7^*	CH	3.28	H-6'''α, H-6'''β
	5'''	73.3	CH	3.28	H-4''', H-6'''β, OH-6'''
	6'''	60.3	CH₂	3.58, 3.66	H-4''', H-5''',OH-6'''
Dα	1''''	92.1	CH	4.91	OH-2'''', OH-1''''	Dα	94.5
	2''''	71.8	CH	3.19	H-4'''', OH-2'''', OH-1''''		74.0
	3''''	73.1	CH	3.66	H-4'''', OH-2'''', OH-3''''		75.7
	4''''	80.5	CH	3.28	H-6''''α, H-3'''', 5'''', 6'''', 6''''β, H-1'', OH-3''''		80.00
	5''''	70.2	CH	3.66	H-4'''', OH-6'''', H-1''''		73.6
	6''''	60.6	CH₂	3.58, 3.66	H-4'''', H-5'''', OH-6''''		63,3
Dβ	1'''''	96.8	CH	4.31	H-2''''', H-5''''', OH-2''''', OH-1'''''	Dβ	98.3
	2'''''	74.3	CH	2.95	H-4''''', OH-2''''', OH-3''''', OH-1'''''		76.5
	3'''''	76.4	CH	3.38	H-2''''', H-4''''', OH-2''''', OH-3'''''		78.7
	4'''''	80.0	CH	3.28	H-5''''', H-3''''', H-6'''''α, H-6'''''β, H-1''', OH-3'''''		79.9
	5'''''	75.0	CH	3.19	H-4''''', OH-6''''', OH-1'''''		77.1
	6'''''	60.7	CH₂	3.58, 3.66	H-4''''', H-5''''', OH-6'''''		63.1