MRI示踪的纳米酶用于级联反应增强的免疫治疗

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隋美菊¹^,², 张磊¹^,², 王瑞芳¹^,², 骆盈盈¹, 李莎¹, 丘茂松¹, 徐秋怡¹^,², 陈代钦¹^,², 陈世桢¹^,²^,³^,^*(

), 周欣¹^,²^,³

MRI-traceable Nanoenzyme for Cascade Catalysis-enhanced Immunotherapy

SUI Meiju¹^,², ZHANG Lei¹^,², WANG Ruifang¹^,², LUO Yingying¹, LI Sha¹, QIU Maosong¹, XU Qiuyi¹^,², CHEN Daiqin¹^,², CHEN Shizhen¹^,²^,³^,^*(

), ZHOU Xin¹^,²^,³

图3. MH NPs的光热和光声性能. (a)近红外激光（808 nm激光，500 mW·cm^-2）照射下MH NPs溶液（500 μg·mL^-1）和H₂O的升温曲线和红外热像图；(b) 808 nm激光（500 mW·cm^-2）照射下不同浓度MH NPs溶液的温度变化曲线；(c)不同功率密度808 nm激光照射下MH NPs溶液（500 μg·mL^-1）的温度变化曲线；(d) MH NPs光热转换效率的计算；(e) 808 nm激光（500 mW·cm^-2）照射循环下MH NPs溶液的温度变化曲线；(f)光声（PA）信号强度与MH NPs溶液浓度的相关性以及不同浓度MH NPs溶液的光声图像

Fig. 3. The photothermal and photoacoustic performance of MH NPs. (a) The heating curve and infrared thermographs of MH NPs solution (500 μg·mL^-1) and H₂O under NIR laser irradiation (808 nm laser, 500 mW·cm^-2); (b) Temperature change curves of MH NPs solutions with various concentrations irradiated by 808 nm laser (500 mW·cm^-2); (c) Temperature change curves of MH NPs solution (500 μg·mL^-1) irradiated by 808 nm laser of different power densities; (d) Calculation of the photothermal conversion efficiency of MH NPs; (e) Temperature change curves of MH NPs solutions under the cyclic irradiation of 808 nm laser (500 mW·cm^-2); (f) Correlation of the photoacoustic signal intensity with the concentrations of MH NPs solutions and photoacoustic images of MH NPs solutions at different concentrations