MRI示踪的纳米酶用于级联反应增强的免疫治疗

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隋美菊¹^,², 张磊¹^,², 王瑞芳¹^,², 骆盈盈¹, 李莎¹, 丘茂松¹, 徐秋怡¹^,², 陈代钦¹^,², 陈世桢¹^,²^,³^,^*(

), 周欣¹^,²^,³

MRI-traceable Nanoenzyme for Cascade Catalysis-enhanced Immunotherapy

SUI Meiju¹^,², ZHANG Lei¹^,², WANG Ruifang¹^,², LUO Yingying¹, LI Sha¹, QIU Maosong¹, XU Qiuyi¹^,², CHEN Daiqin¹^,², CHEN Shizhen¹^,²^,³^,^*(

), ZHOU Xin¹^,²^,³

图4. MH NPs的T₂加权磁共振成像能力. (a)不同pH条件下MH NPs的T₂ MRI图像；(b)不同pH条件下MH NPs的横向弛豫率与锰浓度之间的线性关系；(c)不同pH（pH = 7.4、6.5和5.5）条件下，MH NPs中Mn²⁺的体外释放曲线；(d) MH NPs与不同浓度GSH反应后的T₂ MRI图像；(e) 不同GSH条件下，MH NPs的横向弛豫率与锰浓度之间的线性关系；(f)与不同浓度GSH反应后，MH NPs中Mn²⁺的体外释放曲线

Fig. 4. The T₂-weighted MR imaging capability of MH NPs. (a) T₂ MRI images of MH NPs at various pH conditions; (b) The linear relationship for the transverse relaxation rate of MH NPs as a function of Mn concentration under different pH conditions; (c) In vitro release curve of Mn²⁺ from MH NPs at various pH conditions (pH = 7.4, 6.5, and 5.5); (d) T₂ MRI images of MH NPs after reaction with various concentrations of GSH; (e) The linear relationship for the transverse relaxation rate of MH NPs as a function of Mn concentration under different GSH conditions; (f) In vitro release curve of Mn²⁺ from MH NPs after reaction with various concentrations of GSH