MRI示踪的纳米酶用于级联反应增强的免疫治疗

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隋美菊¹^,², 张磊¹^,², 王瑞芳¹^,², 骆盈盈¹, 李莎¹, 丘茂松¹, 徐秋怡¹^,², 陈代钦¹^,², 陈世桢¹^,²^,³^,^*(

), 周欣¹^,²^,³

MRI-traceable Nanoenzyme for Cascade Catalysis-enhanced Immunotherapy

SUI Meiju¹^,², ZHANG Lei¹^,², WANG Ruifang¹^,², LUO Yingying¹, LI Sha¹, QIU Maosong¹, XU Qiuyi¹^,², CHEN Daiqin¹^,², CHEN Shizhen¹^,²^,³^,^*(

), ZHOU Xin¹^,²^,³

图6. MH NPs的活体生物分布和磁共振、光声成像. (a)静脉注射MH@ICG NPs不同时间点4T1荷瘤小鼠的活体荧光图像；(b)静脉注射MH@ICG NPs后不同时间点4T1荷瘤小鼠肿瘤部位的荧光变化曲线；(c)MH@ICG NPs静脉注射72 h后4T1荷瘤小鼠主要脏器的荧光图像；(d)静脉注射72 h后4T1荷瘤小鼠主要脏器中MH@ICG NPs的半定量分析；(e)静脉注射MH NPs后不同时间点4T1荷瘤小鼠的T₂ MRI图像；(f)静脉注射MH NPs后不同时间点4T1荷瘤小鼠的光声图像；(g)静脉注射MH NPs后不同时间点4T1荷瘤小鼠肿瘤部位T₂ MRI信号变化曲线；(h)静脉注射MH NPs后不同时间点4T1荷瘤小鼠肿瘤部位光声信号变化曲线

Fig. 6. In vivo biodistribution and MRI & PAI performance of MH NPs. (a) In vivo fluorescence images of 4T1 tumor-bearing mice at different time points after intravenous injection with MH@ICG NPs; (b) The fluorescence variation curves of tumor sites in 4T1 tumor-bearing mice at different time points after intravenous injection with MH@ICG NPs; (c) Fluorescence images of major organs of 4T1 tumor-bearing mice after intravenous injection with MH@ICG NPs for 72 h; (d) Semi-quantitive analysis of MH@ICG NPs in major organs of 4T1 tumor-bearing mice after intravenous injection with MH@ICG NPs for 72 h; (e) T₂ MRI images of 4T1 tumor-bearing mice after intravenous injection with MH NPs at different time points; (f) Photoacoustic images of tumor sites in 4T1 tumor-bearing mice after intravenous injection with MH NPs at different time points; (g) The T₂ MRI signal variation curves of tumor sites in 4T1 tumor-bearing mice at different time points after intravenous injection with MH NPs; (h) The photoacoustic signal variation curves of tumor sites in 4T1 tumor-bearing mice at different time points after intravenous injection with MH NPs