19F NMR化学位移编码的cRGD靶向双模态探针多色成像

李娜, 肖龙, 李莎, 刘昱墩, 贾宇舒, 张磊, 陈世桢

19F NMR Chemical Shift-encoded cRGD-targeted Dual-modal Probe for Multicolor Imaging

LI Na, XIAO Long, LI Sha, LIU Yudun, JIA Yushu, ZHANG Lei, CHEN Shizhen

图2 不同取代位点与类型的含氟中间体与NTR响应前后的19F{1H} NMR变化. (a)邻位双氟；(b)间位双氟；(c)对位单氟；(d)邻位六氟. 溶剂为2% DMSO + 98% H2O. 所有19F NMR数据均对1H去耦

Fig. 2 19F{1H} NMR changes of fluorine-containing intermediate molecules with different substitution sites and types before and after NTR activation: (a) ortho-difluoro, (b) meta-difluoro, (c) para-monofluoro, (d) ortho-hexafluoro. The solvent is 2% DMSO and 98% H2O. All 19F NMR data were acquired with 1H decoupling