波谱学杂志

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二型糖尿病大鼠纹状体白质微观结构异常的磁共振影像研究

蔡悦1,2*，王旭霞1,2，刘思婕1,2，郭浩东1,2，陈茜1,2，程琳琳1,3，康彦1,2，林富春1,2   

  1. 1. 中国科学院精密测量科学与技术创新研究院，波谱与原子分子物理国家重点实验室，武汉磁共振中心，湖北 武汉 430071；2. 中国科学院大学，北京 100049；3. 华中科技大学，武汉光电国家研究中心，湖北 武汉 430074
  • 收稿日期:2025-07-23 修回日期:2025-09-08 接受日期:2025-09-08
  • 通讯作者: 蔡悦 E-mail:caiyue192@mails.ucas.ac.cn

Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Rats

CAI Yue1,2,*，WANG Xuxia1,2，LIU Sijie1,2，GUO Haodong1,2，CHEN Xi1,2，CHENG Linlin1,3，KANG Yan1,2，LIN Fuchun1,2   

  1. 1. State Key Laboratory of Spectroscopy and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Wuhan 430071, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China; 3. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China
  • Received:2025-07-23 Revised:2025-09-08 Accepted:2025-09-08
  • Contact: CAI Yue E-mail:caiyue192@mails.ucas.ac.cn

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摘要： 本文旨在通过磁共振成像（MRI）技术探索二型糖尿病（type 2 diabetes mellitus，T2DM）大鼠脑白质结构改变及其病理机制．本研究采用8周高脂饮食加腹腔注射30 mg/kg链脲佐菌素（STZ）建立T2DM模型，造模4周后，通过MRI技术对大鼠进行脑白质可视化分析，通过免疫组化进一步解释MRI指标变化的生理机制．结果发现，T2DM大鼠纹状体白质体积减小，各向异性分数（FA）、平均扩散率（MD）、轴向扩散速率（AD）值降低，径向扩散率（RD）值升高，磷酸化纤维丝（SMI-31）和髓鞘碱性蛋白（MBP）免疫组化提示T2DM组大鼠纹状体存在轴突受损、脱髓鞘．综上所述，弥散张量成像（DTI）结果显示T2DM大鼠纹状体损伤，其参数异常可能是纹状体轴突受损和脱髓鞘的表现，DTI指标有望作为评估糖尿病脑损伤的潜在指标．

关键词: 磁共振成像（MRI）, 弥散张量成像（DTI）, 纹状体, 二型糖尿病

Abstract:

The aim of this study is to explore the structural changes in white matter and its physiological mechanisms in type 2 diabetes mellitus (T2DM) rats through magnetic resonance imaging (MRI) technology. In this study, a T2DM model induced by 8 weeks of high-fat diet and 30mg/kg streptozotocin (STZ). 4 weeks after modeling, visual analysis of white matter in rats was performed by MRI, and the physiological mechanism of MRI index changes was further explained by immunohistology. The results showed that the striatal white matter volume decreased, the fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD) decreased, and radial diffusivity (RD) increased in T2DM rats. Immunostain of phosphorylated neurofilament (SMI-31) and myelin basic protein (MBP) indicated axonal damage and demyelination of striatum in T2DM rats. In conclusion, the striatal injury in T2DM rats was observed by diffusion tensor imaging (DTI), and abnormal DTI index may be a manifestation of striatal axonal damage and demyelination, which can potentially be used as surrogates for evaluating diabetic brain injuries.

Key words: MRI, DTI, striatum, T2DM

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