31P 磁共振波谱技术进展及其在精神障碍研究中的应用

doi:10.11938/cjmr2026-3225

波谱学杂志

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³¹P 磁共振波谱技术进展及其在精神障碍研究中的应用

赖成1,2，薛蓉1,2,3，左真涛1,2,3,4,5*

1. 中国科学院生物物理研究所，认知科学与心理健康全国重点实验室，北京磁共振脑成像中心，北京 100101；2. 中国科学院大学生命学院，北京 101408；3. 中国科学院大学中丹中心，北京 101400；4. 中国科学院生物物理研究所，多模态跨尺度生物医学成像设施，北京 101407；5. 中国科学院生物物理研究所，脑认知机理与脑机融合交叉研究平台，北京 101407

收稿日期:2026-07-10 修回日期:2026-09-10 接受日期:2026-10-08
通讯作者: 左真涛 E-mail:zuozt@ibp.ac.cn
基金资助:
科技创新2030—“脑科学与类脑研究”重大项目(2022ZD0211901); 国家重点研发计划资助项目(2023YFF0714204); 中国科学院青年创新促进会(2021091); 中国科学院稳定支持基础研究领域青年团队计划(YSBR-068); 中国科学院资助项目(2024GZL003)

Advances in ³¹P Magnetic Resonance Spectroscopy and Its Applications in Psychiatric Disorders

LAI Cheng1,2，XUE Rong1,2,3，ZUO Zhentao1,2,3,4,5*

1. State Key Laboratory of Cognitive Science and Mental Health, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China; 3. Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 101400, China; 4. National Multimode Trans-Scale Biomedical Imaging Center, Institute of Biophysics, Chinese Academy of Sciences, Beijing 101407, China; 5. Platform for Interdisciplinary Research on Brain Cognition Mechanisms and Brain-computer Integration, Chinese Academy of Sciences, Beijing 101407, China.

Received:2026-07-10 Revised:2026-09-10 Accepted:2026-10-08
Contact: ZUO Zhentao E-mail:zuozt@ibp.ac.cn

摘要/Abstract

摘要： ³¹P磁共振波谱（phosphorus-31 magnetic resonance spectroscopy，³¹P MRS）可无创检测脑内高能磷酸化合物、膜磷脂代谢物和细胞内pH，并结合磁化转移技术评估酶促反应动力学，为研究精神障碍中的线粒体功能异常、能量代谢失衡及膜磷脂周转紊乱提供独特手段。传统³¹P MRS技术，包括³¹P磁共振波谱成像（phosphorus-31 magnetic resonance spectroscopic imaging，³¹P MRSI）受信噪比低、空间分辨率不足和采集耗时等限制。近年来，超高场磁共振成像、多通道射频线圈、快速空间-波谱编码及先进重建方法不断提升其采集效率与定量能力。本文综述³¹P MRS/MRSI的基本原理、采集与定量方法及其在主要精神障碍中的应用，并讨论研究结果异质性的潜在来源。未来需进一步推进绝对定量、动态代谢测量、多中心标准化及大样本纵向研究。

关键词: 31P磁共振波谱, 31P磁共振波谱成像, 精神障碍, 能量代谢, 磁化转移波谱

Abstract: Phosphorus-31 magnetic resonance spectroscopy (³¹P MRS) enables the noninvasive assessment of cerebral high-energy phosphates, membrane phospholipid metabolites, and intracellular pH. When combined with magnetization transfer techniques, it can also evaluate enzyme-catalyzed reaction kinetics, providing a unique tool for investigating mitochondrial dysfunction, impaired energy metabolism, and abnormal membrane phospholipid turnover in psychiatric disorders. Conventional ³¹P MRS, including phosphorus-31 magnetic resonance spectroscopic imaging (³¹P MRSI), are limited by low signal-to-noise ratio, insufficient spatial resolution, and time-consuming acquisitions. Recent advances in ultra-high-field magnetic resonance imaging, multichannel radiofrequency coils, rapid spatial-spectral encoding, and advanced reconstruction methods have improved acquisition efficiency and quantitative capability. This review summarizes the basic principles, acquisition and quantification methods, and applications of ³¹P MRS/MRSI in major psychiatric disorders, and discusses potential sources of heterogeneity across studies. Future work should further advance absolute quantification, dynamic metabolic measurements, multicenter standardization, and large-scale longitudinal studies.

Key words: 31P MRS, 31P MRSI, psychiatric disorders, energy metabolism, magnetization transfer spectroscopy

赖成, 薛蓉, 左真涛. ³¹P 磁共振波谱技术进展及其在精神障碍研究中的应用[J]. 波谱学杂志, doi: 10.11938/cjmr2026-3225.

LAI Cheng, XUE Rong, ZUO Zhentao. Advances in ³¹P Magnetic Resonance Spectroscopy and Its Applications in Psychiatric Disorders[J]. Chinese Journal of Magnetic Resonance, doi: 10.11938/cjmr2026-3225.

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³¹P 磁共振波谱技术进展及其在精神障碍研究中的应用

Advances in ³¹P Magnetic Resonance Spectroscopy and Its Applications in Psychiatric Disorders

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