Abstract: Today chemical research is hardly conceivable without nuclear magnetic resonance.It has proved to be an exceedingly rich source of information for exploring the structure of molecules in solution, for the investigation of solid materials, and for the study of molecular dynamics. In order to cope with the over whelming information content, an extension to two-dimensional spectroscopy turned out to be indispensible. Two-dimensional spectroscopy has contributed, since its introduction 12 years ago a large number of new powerful techniques for the elucidation of coupling networks by 2D correlation spectroscopy,for the measurement of internuclear distances by 2D cross——relaxation spectroscopy, and for the investigation of chemical exchange networks by 2D exchange spectrosoc-py. These new techniques are particularly elusive for the analysis of large mol-ecules in chemistry and in biology.