Abstract: The stereochcmical and structural analysis of two sesquiterpenoids was carried out using nuclear magnetic resonance spectroscopy. Several methods, including ¹H-¹H two-dimensional shift correlation spectroscopy, ¹³C-¹H two-dimensional shift correlation spectroscopy, COLOC (COrrelation spectroscopy via LOng range Coupling), DEPT (Distortionless Enhancement by Polarization Transfer) were used for chemical shift assignment and configurational analysis. Nuclear Overhauser Effect Spectroscopy was used to establish the stereochemistry. This investigation demonstrates the power of two-dimensional NMR techniques and the Nuclear Overhauser Effect (NOE) in the structural determination of natural products.

Key words: Sesquiterpenoid, 2D NMR, NOE