Abstract: A series of copolymcrs of β-Cyclodextrin (β-CD) with Epichlorohydrin (EP) was determined by means of ¹H NMR in D₂O or DMSO-d₆ at 60,300 and 400 MHz, and their spectral assignments were given out. Copolymerization mechanism could be ascribed to a nucleophilic addition of hydroxyl group to epoxy group as an active centre. When EP:β-CD=n ≤ 3,the copolymeric molecular chains showed linear or branched structure at β-CD matrix; n ≥ 5, crosslinking network appeared in the chains. The larger n value (here, n ≤ 12), the larger M. W., and the higher crosslinking degree.

Key words: Copolymers of β-Cyclodextrin with Epichlorohydrin, ¹H NMR, Molecular chain structure