STUDY ON THE SYNTHESIS AND RELAXIVITY OF NITROXYL-LABELED POLYPHOSPHATES

Chinese Journal of Magnetic Resonance ›› 1996, Vol. 13 ›› Issue (5): 417-422.

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STUDY ON THE SYNTHESIS AND RELAXIVITY OF NITROXYL-LABELED POLYPHOSPHATES

Yu Kaichao, Zhuo Renxi

Department of Chemistry, Wuhan University, Wuhan 430072

Received:1996-03-25 Revised:1996-04-26 Published:1996-10-05 Online:2018-01-17

Abstract

Abstract: Seven spin-labeled polyphosphates were synthesized by the polycondensation of O-(1-oxyl-2, 2, 6, 6-tetramethyl-4-piperidyl) phosphoric acid dichloride with tetraethylene glycol, triethylene glocol, diethylene glycol, 1, 6-hexanediol, 1,8-octandiol, N-ethyldiethanolamine and N-butyldiethanolamine, respectively.The structures of these stable nitroxyl-labeled polyphosphates were characterized by IR, UV, ESR, VPO and Elemental analysis. The relaxivity (R_i) of polyphosphate 3a,3c and 3d was investigated.

Key words: Nitroxide, Spin-labeling, Polyphosphate, MRI contrast agent, Relaxivity

Yu Kaichao, Zhuo Renxi. STUDY ON THE SYNTHESIS AND RELAXIVITY OF NITROXYL-LABELED POLYPHOSPHATES[J]. Chinese Journal of Magnetic Resonance, 1996, 13(5): 417-422.

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STUDY ON THE SYNTHESIS AND RELAXIVITY OF NITROXYL-LABELED POLYPHOSPHATES

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