THE 1H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES

Chinese Journal of Magnetic Resonance ›› 1996, Vol. 13 ›› Issue (6): 583-587.

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THE ¹H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES

Peng Shiqi¹, Guo Ming¹, Mao Xian², Ekkehard Winterfeldt³

1. College of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083;
2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute, The Chines. Academy of Sciences, Wuhan 430071;
3. Institut fur Organische Chemie, Universitat Hannover, Germany

Received:1996-06-06 Revised:1996-07-29 Published:1996-12-05 Online:2018-01-17

Abstract

Abstract: The 6-substituted 3-acety1-1,4,6,7-tetrahydro-4-oxoindolo-[2,3-a]quinolizines exhibited antitumer activity and the potency related to 6-substituent.In the present paper 6-methoxycarbonyl-,6-carboxy-,6-amido-,6-hydroxymethyl-and 6-acetylacetomethy1-3-acety1-1,4,6,7-tetrahydro-4-oxoindolo[2,3-a] quinolizine were synthesized,their ¹H NMR are reported,the relationships between HL₆₀ inhibitions and the chemical shifts for some protons are discussed.

Key words: Indoloquinolizidone, ¹H NMR, Antitumer activity

Peng Shiqi, Guo Ming, Mao Xian, Ekkehard Winterfeldt. THE ¹H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES[J]. Chinese Journal of Magnetic Resonance, 1996, 13(6): 583-587.

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THE ¹H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES

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