Abstract: A NMR method for measuring selective homonuclear NOE effect under spin-locked conditions,called 1D ROE difference spectroscopy, was proposed. This technique provides a single and fast way to obtain NOE in complex overlapping spectral regions, and is particularly suitable for the molecules which have a motional correlation time τ_c near condition ωτ_c=1, where ω is the angular Larmor frequency. The 1D ROE spectrum obtained show clear lineshapes and good resolution. The dispersive signals commonly encountered in the conventional NOE difference spectra are much less pronouned in the 1D ROE spectra obtained by this technique.

Key words: 1D ROE difference spectroscopy, NMR technique