Abstract: The alternating cyclocopolymer of DVE-MA possesses a wide spectrum of biological activities.including antitumor. Recent research on the structure of a variety of cyclocopolymer has raised a question about the ring structure of this cyclocopolymer. In this paper we report for the first time 2D ¹H-¹H COSY. ¹-¹³ C COSY and J-resolved spectroscopy to elueidate the 400MHz NMR spectrum of eyclocopolymer of DVE-MA,combined with the PC-MOD calenlation of coupling constant and minimal energy in comparison with model compounds.We discussed the relation of stereochemistry of the copolymer to energy.

Key words: Alternating cyclopolymer of DVE-MA, PC-MOD calculation, 2D NMR