Chinese Journal of Magnetic Resonance ›› 1997, Vol. 14 ›› Issue (4): 347-352.

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SYNTHESIS AND RELAXIVITY OF DTPA DIESTER Gd(Ⅲ) COMPLEXES

Bai Zhengwu, Zhuo RenXi   

  1. Department of Chemistry, Wuhan University, Laboratory of Biomedical Polymer Materials of the State Education Commission, Wuhan 430072
  • Received:1997-01-28 Revised:1997-03-31 Published:1997-08-05 Online:2018-01-22

Abstract: Polyaminocarboxylate ligands were synthesized by the reaction of diethylenetriaminepentaacetic dianhydride with glycol monoether, and their Gd(Ⅲ) complexes were also prepared. The structures of the ligands and complexes were confirmed by IR, 1H NMR spectra and elemental anaJysis. The relaxivity of these Gd(Ⅲ) complexes were investigated and the data indicated that three of them showed higher relaxivity as compared to Gd(DTPA).

Key words: MRI contrast agent, Gadolinium complex, Relaxivity