Chinese Journal of Magnetic Resonance ›› 1997, Vol. 14 ›› Issue (5): 431-436.

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1H NMR OF 6-AMINO ACID SUBSTITUTED INDOLOQUINOLIZIDONES

Peng Shiqi1, Guo Ming1, Mao Xian2, Ekkehard Winterfeldt3   

  1. 1 College of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083;
    2 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute, The Chinese Academy of Sciences, Wuhan 430071;
    3 Institut für Organische Chemie, Universitatät Hannover, Germany
  • Received:1997-04-18 Revised:1997-06-09 Published:1997-10-05 Online:2018-01-22

Abstract: In the design of indoloquinolizidone anticancers N-butoxycarbonylglycine, monobenzyl ester of Nbutoxycarbonyl-L-asparagic acid, N-butoxycarbonyl-L-glutamine and glycine were introduced into the 6-position of the indoloquinolizidone respectively based on the antimetabolic theory. In the present paper the 1H NMR data and conformation analysis are reported.

Key words: Amino acids, Indoloquinolizidone, 1H NMR