NMR STUDY ON A NEW HETISINE-TYPE DITERPENOID ALKALOID FROM ACONITUM COREANUM

Chinese Journal of Magnetic Resonance ›› 1999, Vol. 16 ›› Issue (5): 403-408.

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NMR STUDY ON A NEW HETISINE-TYPE DITERPENOID ALKALOID FROM ACONITUM COREANUM

Miao Zhenchun¹, Feng Rui², Zhou Yongxin¹, Li Guangyu², Liu Jinghan³, Hao Zhigang³

1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850;
2. National Center of Biomedical Analysis, Academy of Military Medical Sciences, Beijing 100850;
2. China Pharmaceutical University, Nanjing 210009

Received:1999-04-06 Revised:1999-05-28 Published:1999-10-05 Online:2018-01-13

Abstract

Abstract: A new hetisine-type diterpenoid alkaloid 1 has been isolated from the total alkaloids of the Aconitum coreanum. Its structure has been established as 13-acetyl-14-hyroxy-2-prpionyl-hetisine by selective long-range DEPT NMR techique which has been used to connect spin systems separated by quaternary carbons and heteroatoms. The results showed that selective long-range DEPT NMR technique is very effective and convenient for the structure determination and spectral assignment of this class of compounds.

Key words: Selective long-range DEPT, Diterpenoid alkaloid, Structural determination

Miao Zhenchun, Feng Rui, Zhou Yongxin, Li Guangyu, Liu Jinghan, Hao Zhigang. NMR STUDY ON A NEW HETISINE-TYPE DITERPENOID ALKALOID FROM ACONITUM COREANUM[J]. Chinese Journal of Magnetic Resonance, 1999, 16(5): 403-408.

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NMR STUDY ON A NEW HETISINE-TYPE DITERPENOID ALKALOID FROM ACONITUM COREANUM

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