IN VIVO 19F NMR STUDY ON METABOLISM OF 5-FLUOROURACIL IN MURINE LIVER AND IMPLANTED TUMOR

Chinese Journal of Magnetic Resonance ›› 1996, Vol. 13 ›› Issue (3): 239-244.

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IN VIVO ¹⁹F NMR STUDY ON METABOLISM OF 5-FLUOROURACIL IN MURINE LIVER AND IMPLANTED TUMOR

Yan Xianzhong¹, Li Hua², Du Zehan¹, Ruan Jinxiu²

1. National Center of Biomedical Analysis, Academy of Military Medical Sciences, Beijing 100850;
2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

Received:1995-08-09 Revised:1995-09-11 Published:1996-06-05 Online:2018-01-17

Abstract

Abstract: Metabolism of 5-fluorouracil(5FU) in mouse liver and implanted S180 tumor was studied using in vivo ¹⁹F NMR spectroscopy. The half-life of 5FU elimination is about 15-20min in liver and 50-60min in tumor.Catabolites of 5FU,fluorouredopropanic acid and α-fluoro-β-analine,were observed in livel, while only the fluoronucleotides,anabolites of 5FU,were observed in tumor. The results show that NMR spectroscopy is a powerful method for metabolic and pharmacokinetic studies.

Key words: ¹⁹F NMR, 5-fluorouracil, Liver, Tumor

Yan Xianzhong, Li Hua, Du Zehan, Ruan Jinxiu. IN VIVO ¹⁹F NMR STUDY ON METABOLISM OF 5-FLUOROURACIL IN MURINE LIVER AND IMPLANTED TUMOR[J]. Chinese Journal of Magnetic Resonance, 1996, 13(3): 239-244.

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IN VIVO ¹⁹F NMR STUDY ON METABOLISM OF 5-FLUOROURACIL IN MURINE LIVER AND IMPLANTED TUMOR

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