Chinese Journal of Magnetic Resonance ›› 1983, Vol. 1 ›› Issue (1): 123-126.

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DETERMINATION OF GARAMINE PKa BY CARBON-13 NUCLEAR MAGNETIC RESONANCE

Gao Xiaoju1, Liu Shuxun2   

  1. 1. Tung-ji University;
    2. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1983-02-25 Published:1983-03-05 Online:2018-01-23

Abstract: Garamine is an aminoglycoside with biological activity Its PKa values where determined over the PH range 2-13 by C-13NMR method. Data obtained in the experiment were analyzed by nonlinear regression method.Three PKa values have been obtained:PK1=5.45. PK2=6.75, PK3=8.70. The present information can provide a basis for further study of metabolism of aminoglyco -sides in livnig body.