Chinese Journal of Magnetic Resonance

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DYNAMIC EQUILIBRIUM BETWEEN THE TAUTOMERS OF GOSSYPOL STUDIED BY 2D NMR

SHEN Ying-lin, YANG Sheng-hua, YING Wei,  YAN Xiao-hua,  MA Xue-yi*   

  1. National Laboratory of Applied Organic Chemistry, Department of Chemistry Lanzhou University, Lanzhou 730000, China
  • Received:2003-05-06 Revised:2003-05-26 Published:2003-12-05 Online:2003-12-05
  • About author:*Correspondence author: Ma Xue-yi,E-mail:maxueyi@lzu.edu.cn,Tel:(0931)3937749.

Abstract:

Three tautomers of gossypol, aldehyde (I), lacto (II) and ketal (III), exist in CDCl\-3, and are in equilibrium. 1H NMR spectra of the three tautomers were assigned by means of 1D and 2D NMR techniques including 1H-1H COSY, DEPT, HMQC (1H Detected Heteronuclear Multiple Quantum Coherence) and HMBC (1H Detected Heteronuclear Multiple Bond Connectivity) experiments.

Key words: 2D NMR, gossypol, dynamic equilibrium, tautomer,  chemical shift assignment

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