波谱学杂志 ›› 2015, Vol. 32 ›› Issue (2): 181-194.doi: 10.11938/cjmr20150204
彭俊辉，赵德彪，文彬，张志勇*
收稿日期:2015-02-06
修回日期:2015-05-08
出版日期:2015-06-05
在线发表日期:2015-06-05
作者简介:*通讯联系人：张志勇，电话：+86-551-63600854，E-mail: zzyzhang@ustc.edu.cn.
基金资助:The National Key Basic Research Program of China (2013CB910203), the National Natural Science Foundation of China (31270760), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB08030102), the Specialized Research Fund for the Doctoral Program of Higher Education (20113402120013).
PENG Jun-hui，ZHAO De-biao，WEN Bin，ZHANG Zhi-yong*
Received:2015-02-06
Revised:2015-05-08
Published:2015-06-05
Online:2015-06-05
About author:PENG Jun-hui (1989-), male, born in Jiangxi, PhD., his research focuses on Computational Biology, Tel: +86-551-63600854, E-mail: jhpanda@mail.ustc.edu.cn.
*Corresponding author.: ZHANG Zhi-yong, Tel: +86-551-63600854, E-mail: zzyzhang@ustc.edu.cn.
Supported by:The National Key Basic Research Program of China (2013CB910203), the National Natural Science Foundation of China (31270760), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB08030102), the Specialized Research Fund for the Doctoral Program of Higher Education (20113402120013).
摘要：
近年来，结构生物学研究越来越注重生物大分子复合物的解析，因为许多重要生物学过程都离不开复合物的参与．溶液核磁共振是目前重要的结构解析方法之一．X射线小角散射(SAXS)作为一种新的结构生物学实验手段，近年来发展迅速．SAXS 能提供生物大分子复合物的较低分辨率结构信息，而核磁共振能解析复合物中各个亚基的原子分辨率结构．此外，通过核磁共振还能得到亚基之间的界面、取向以及距离信息．因此近年来通过计算机模拟，整合核磁共振和SAXS 不同分辨率的结构信息，可以用来搭建生物大分子复合物的结构模型．该综述重点介绍这方面的研究进展．
中图分类号:
彭俊辉，赵德彪，文彬，张志勇*. 核磁共振、X 射线小角散射以及计算机模拟相结合构建生物大分子复合物的结构模型[J]. 波谱学杂志, 2015, 32(2): 181-194.
PENG Jun-hui，ZHAO De-biao，WEN Bin，ZHANG Zhi-yong*. Determining Structural Models of Biomolecular Complexes Integrating Nuclear Magnetic Resonance, Small-Angle X-ray Scattering and Computational Simulations[J]. Chinese Journal of Magnetic Resonance, 2015, 32(2): 181-194.
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