柠檬醛长时程嗅觉吸入的脑功能活动MEMRI研究

doi:10.11938/cjmr20192766

波谱学杂志 ›› 2020, Vol. 37 ›› Issue (3): 311-320.doi: 10.11938/cjmr20192766

所属专题：虚拟专刊：MRI方法与应用

柠檬醛长时程嗅觉吸入的脑功能活动MEMRI研究

方文恒^1,2

1. 波谱与原子分子物理国家重点实验室, 武汉磁共振中心(中国科学院武汉物理与数学研究所), 湖北武汉 430071;
2. 中国科学院大学, 北京 100049

收稿日期:2019-07-12 出版日期:2020-09-05 在线发表日期:2019-09-27
通讯作者: 方文恒,Tel:15271802086,E-mail:wenheng.fang@gmail.com. E-mail:wenheng.fang@gmail.com
基金资助:
国家自然科学基金资助项目（81171302）.

Brain Activations in Response to Prolonged Citral Inhalation Detected by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)

FANG Wen-heng^1,2

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2019-07-12 Published:2020-09-05 Online:2019-09-27

摘要/Abstract

摘要： 本文使用设计的嗅觉吸入装置使大鼠吸入挥发性柠檬醛或无气味空气，之后使用锰增强磁共振成像（MEMRI）的方法，观察长时程（24 h）吸入柠檬醛之后，大鼠脑功能活动变化情况．基于体素分析和感兴趣区（ROI）分析结果显示，与对照组相比，长时程吸入柠檬醛组大鼠伏隔核中心部（AcbC）、嗅小球层（GL）等脑区功能活动增强；而该组大鼠视皮层（VC）、听觉皮层（AC）、压后皮层（RSC）等脑区锰累积显著减少．且长时程吸入柠檬醛之后，大鼠脑区GL与关联的脑区功能相关性显著增强．从而表明MEMRI可用于长时程嗅觉吸入刺激的脑功能研究，并极具应用前景．

关键词: 锰增强磁共振成像（MEMRI）, 柠檬醛, 嗅觉吸入, 脑功能活动

Abstract: In this study, an olfactory inhalation instrument was devised to allow the rats to inhale volatile citral or odorless air. Manganese-enhanced magnetic resonance imaging (MEMRI) was used to reveal changes of accumulative brain activities after a 24 h inhalation of volatile citral. Compared with the control group, the rats in the citral group showed increased functional activities in the core of nucleus accumbens (AcbC) and olfactory glomerular layer (GL), and decreased Mn²⁺ accumulation in the brain regions of visual cortex (VC), auditory cortex (AC) and retrosplenial cortex (RSC). Functional correlations between the GL and associated brain regions increased after citral inhalation. These results suggested that MEMRI might be used to detect brain activation associated with sustained olfactory stimulation.

Key words: manganese-enhanced magnetic resonance imaging (MEMRI), citral, olfactory inhalation, functional brain activation

中图分类号:

O482.53

方文恒. 柠檬醛长时程嗅觉吸入的脑功能活动MEMRI研究[J]. 波谱学杂志, 2020, 37(3): 311-320.

FANG Wen-heng. Brain Activations in Response to Prolonged Citral Inhalation Detected by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)[J]. Chinese Journal of Magnetic Resonance, 2020, 37(3): 311-320.

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柠檬醛长时程嗅觉吸入的脑功能活动MEMRI研究

Brain Activations in Response to Prolonged Citral Inhalation Detected by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)

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