Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Rats

doi:10.11938/cjmr2025-3177

Chinese Journal of Magnetic Resonance

Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Rats

CAI Yue1,2,*，WANG Xuxia1,2，LIU Sijie1,2，GUO Haodong1,2，CHEN Xi1,2，CHENG Linlin1,3，KANG Yan1,2，LIN Fuchun1,2

1. State Key Laboratory of Spectroscopy and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Wuhan 430071, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China; 3. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China

Received:2025-07-23 Revised:2025-09-08 Accepted:2025-09-08
Contact: CAI Yue E-mail:caiyue192@mails.ucas.ac.cn

Abstract

Abstract:

The aim of this study is to explore the structural changes in white matter and its physiological mechanisms in type 2 diabetes mellitus (T2DM) rats through magnetic resonance imaging (MRI) technology. In this study, a T2DM model induced by 8 weeks of high-fat diet and 30mg/kg streptozotocin (STZ). 4 weeks after modeling, visual analysis of white matter in rats was performed by MRI, and the physiological mechanism of MRI index changes was further explained by immunohistology. The results showed that the striatal white matter volume decreased, the fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD) decreased, and radial diffusivity (RD) increased in T2DM rats. Immunostain of phosphorylated neurofilament (SMI-31) and myelin basic protein (MBP) indicated axonal damage and demyelination of striatum in T2DM rats. In conclusion, the striatal injury in T2DM rats was observed by diffusion tensor imaging (DTI), and abnormal DTI index may be a manifestation of striatal axonal damage and demyelination, which can potentially be used as surrogates for evaluating diabetic brain injuries.

Key words: MRI, DTI, striatum, T2DM

CAI Yue1, 2, WANG Xuxia1, 2, LIU Sijie1, 2, GUO Haodong1, 2, CHEN Xi1, 2, CHENG Linlin1, 3, KANG Yan1, 2, LIN Fuchun1, 2. Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Rats[J]. Chinese Journal of Magnetic Resonance, doi: 10.11938/cjmr2025-3177.

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Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Rats

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