Abstract:

This study investigates the correlation between ¹²⁹Xe ventilation functional MRI and CT-detected pulmonary lesion types. We performed ¹²⁹Xe ventilation functional MRI and CT scans on a sample of 143 patients, subsequently analyzing the relationship between lung ventilation function at the lobe level and CT lesion types. The findings suggest that the ventilation function from ¹²⁹Xe MRI was consistent with CT results in the majority of lung lobes (74.6%). The ventilation function impairment of lung correlates with CT lesion types, particularly in instances of mixed diseases and emphysema/bullae, which are more prone to induce lung ventilation dysfunction. Moreover, distinct ventilation patterns are observed among different lesion types. That is, the data from both ¹²⁹Xe ventilation functional MRI and CT provide complementary insights. The preliminary finding of this study offers data support for evaluating lung ventilation function caused by lung lesions, and provides more references for clinical imaging diagnosis, thereby contributing to the refinement of diagnostic and therapeutic strategies for pulmonary diseases.

Key words: hyperpolarized ¹²⁹Xe MRI, pulmonary ventilation functional MRI, lung CT, lung diseases