1H, 13C NMR SPECTRAL ANALYSIS AND STRUCTURAL IDENTIFICATION OF TRANILAST

Chinese Journal of Magnetic Resonance ›› 1989, Vol. 6 ›› Issue (3): 352-357.

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¹H, ¹³C NMR SPECTRAL ANALYSIS AND STRUCTURAL IDENTIFICATION OF TRANILAST

Shen Lianfang¹, Hu Jianzhi¹, Yuan Hanzhen¹, Deng Yuanwei², Zhu Jie², Peng Chongying², Tang Weigao², Mao Wenren²

1. Lab. of Mag. Res. and At. and Mol. Phys., Wuhan Inst. of Phys., Academia Sinica, Wuhan;
2. School of Pharmacy, West China University of Medical Sciences, Chengdu

Received:1988-08-20 Published:1989-09-05 Online:2018-01-22

Abstract

Abstract: In this paper, HomoCOSY and Hetero-CHCOR 2D NMR techniques were used to analyze and assign the ¹H and ¹³C NMR spectra of Tranilast, 2-[[3-(3, 4-Dinethoxy-phcnyl)-1-oxo-2-propenyl] amino] benzoic acid. ¹³C relaxation times (T₁) and variable temperature experiments were used also to identify the structure of the synthesized title compound. Simulated proton spectrum was used to confirm the results.

Key words: Tranilast, 2D NMR, ¹H NMR, ¹³C NMR and Relaxation times

Shen Lianfang, Hu Jianzhi, Yuan Hanzhen, Deng Yuanwei, Zhu Jie, Peng Chongying, Tang Weigao, Mao Wenren. ¹H, ¹³C NMR SPECTRAL ANALYSIS AND STRUCTURAL IDENTIFICATION OF TRANILAST[J]. Chinese Journal of Magnetic Resonance, 1989, 6(3): 352-357.

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¹H, ¹³C NMR SPECTRAL ANALYSIS AND STRUCTURAL IDENTIFICATION OF TRANILAST

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