Chinese Journal of Magnetic Resonance

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CHEMICAL STRUCTURE OF REALOXIFEN HYDROCHLORIDE DETERMINED BY NMR TECHNIQUES

HAN Hai1, LI Zhang-wan2, ZHANG Qiang2, ZHENG Hu2, WENG Ling-ling2   

  1. 1.Department of Pharmacy, Jinan University, Guangzhou 510632, China;
    2.Department of Pharmacy, Sichuan University, Chengdu 610061, China
  • Received:2003-02-27 Revised:2003-07-18 Published:2003-12-05 Online:2003-12-05

Abstract:

Realoxifen hydrochloride is a new drug that can be used for the prevention and treatment of osteoporosis and other diseases caused by osteoporosis. In
 this study, NMR techniques, including DEPT, two-dimensional 1H-1H COSY, HMQC and HMBC, were used for the elucidation of its structure.

Key words: 2D NMR, Realoxifen hydrochloride, Structure,  Spectroscopy

CLC Number: