Spectral Data Deduced Structure of New Drug Lomerizine Dihydrochloride

Chinese Journal of Magnetic Resonance ›› 2006, Vol. 23 ›› Issue (3): 341-348.

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Spectral Data Deduced Structure of New Drug Lomerizine Dihydrochloride

CHEN Yue, LI Jian-feng, WEI Ya-bing, SHEN Jing-shan

1.Nanjing University of Technology, Nanjing 210009; 2.Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203

Received:2005-11-30 Revised:2006-01-19 Published:2006-09-05 Online:2009-12-05
Contact: WEI Ya-bing

Abstract

Abstract: The ultraviolet spectrum, infrared spectrum, 1D and 2D nuclear magnetic resonance (¹H NMR, ¹³C NMR, ¹H-¹H COSY, HMQC and HMBC) spectra and mass spectra of new drug lomerizine dihydrochloride were reported and interpreted. All the NMR signals were assigned. Based on the mass spectral data, the possible fragmentation pathways were discussed. The infrared spectrum was analyzed to derive the types of vibration of the functional groups of this compound. The structure of the compound was determined.

Key words: nuclear magnetic resonance, structure elucidation, lomerizine dihydrochloride, ultraviolet spectrum, infrared spectrum, mass spectrum

CLC Number:

R927

CHEN Yue, LI Jian-feng, WEI Ya-bing, SHEN Jing-shan. Spectral Data Deduced Structure of New Drug Lomerizine Dihydrochloride[J]. Chinese Journal of Magnetic Resonance, 2006, 23(3): 341-348.

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Spectral Data Deduced Structure of New Drug Lomerizine Dihydrochloride

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