Chinese Journal of Magnetic Resonance ›› 2006, Vol. 23 ›› Issue (4): 523-527.

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An NMR Study on Entecavir Sodium

FANG Yu-chun*; YANG Xi-hong; LIU Wei-zhong; ZHU Wei-ming; GU Qian-qun   

  1. (Institute of marine drugs, Ocean University of China, Qingdao 266003)
  • Received:2005-12-05 Revised:2006-04-24 Published:2006-12-05 Online:2009-12-05
  • Contact: FANG Yu-chun

Abstract: Entecavir sodium, an antiviral pro-drug, was a derivative of entecavir. In this study, the 1H and 13C NMR chemical shifts of the compound were completely assigned using 2D NMR techniques, including HMQC, HMBC and 1H-1H COSY. The relative stereochemistry was established by the NOESY method.

Key words: nuclear magnetic resonance, chemical shift, entecavir sodium, pro-drug

CLC Number: