The Phosphorylation Reaction between Daidzein and Di-isopropyl Phosphite Studied by NMR and ESI-MS/MS

Chinese Journal of Magnetic Resonance ›› 2007, Vol. 24 ›› Issue (1): 85-90.

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The Phosphorylation Reaction between Daidzein and Di-isopropyl Phosphite Studied by NMR and ESI-MS/MS

CHEN Xiao-lan¹*；SHI Xiao-na¹；QU Ling-bo¹；YUAN Jin-wei¹；LU Jian-sha¹；ZHAO Yu-fen^1,2

(1.Key Laboratory of Chemical Biology Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China; 2.The Key Laboratory for Bioorganic Phosphorus Chemistry & Chemical Biology (Tsinghua University), Ministry of Education, Beijing 100084, China)

Received:2006-03-01 Revised:2006-08-17 Published:2007-03-05 Online:2009-12-05
Contact: Chen Xiao-lan

Abstract

Abstract: The Atheron-Todd reaction has been used extensively for synthesis of phosphates and phosphoroamidates. In this study, we showed that daidzein can be phosphorylated by a modified Atheron-Todd procedure in which dialkyl phosphite and tetrachloromethane mixture was dropped into a mixed solution of daidzein, trithylamine and DMF. The reaction product was obtained with good yield, whose structure was determined by NMR, ESI-MS and X-ray crystallography.

Key words: NMR, ESI-MS, daidzein, phosphorylation, X-ray crystallography

CLC Number:

O627.51

CHEN Xiao-lan¹*；SHI Xiao-na¹；QU Ling-bo¹；YUAN Jin-wei¹；LU Jian-sha¹；ZHAO Yu-fen^1,2. The Phosphorylation Reaction between Daidzein and Di-isopropyl Phosphite Studied by NMR and ESI-MS/MS[J]. Chinese Journal of Magnetic Resonance, 2007, 24(1): 85-90.

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The Phosphorylation Reaction between Daidzein and Di-isopropyl Phosphite Studied by NMR and ESI-MS/MS

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