QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d6 AND CDCl3 USING 2D EXSY

Chinese Journal of Magnetic Resonance ›› 1999, Vol. 16 ›› Issue (1): 21-27.

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QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d₆ AND CDCl₃ USING 2D EXSY

Du Chen, Mao Xi'an

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071

Received:1998-11-02 Revised:1998-12-01 Published:1999-02-05 Online:2018-01-11
Supported by:
Project supported by the National Natural Science Foundation of China under the number of 29725307.

Abstract

Abstract: NMR two dimensional (2D) exchange spectroscopy (EXSY) is used to study the exchange dynamics of mobile protons in a small pseudopeptide Cbz-Ser-Tyr-OC₆H₁₃. It is shown by a quantitative study that the exchange rates for the four mobile protons in this molecule with water are in the order Ser-OH~Tyr-OH > Ser-NH > Tyr-NH, under the given experimental conditions with dimethylsulfoxide and chloroform as solvents. Local structures for the amino groups in different solutions are described.

Key words: NMR, Proton Exchange, Peptide, Organic Solvents

Du Chen, Mao Xi'an. QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d₆ AND CDCl₃ USING 2D EXSY[J]. Chinese Journal of Magnetic Resonance, 1999, 16(1): 21-27.

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QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d₆ AND CDCl₃ USING 2D EXSY

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