Recent Developments and Applications of  NMR-Based Metabonomics

Abstract

Abstract:

The definition of metabonomics as “the quantitative measurement of the dynamic multi-parametric metabolic response of living systems to pathophysiological stimuli or genetic modification”is now becoming widely known. Here the role that metabonomics has in modern systems biology is reviewed and the techniques used are summarised. This article concentrates on NMR spectroscopic methods but the use of mass spectrometry is increasing, and this is usually prefaced by a separations step using HPLC. Some modern developments in NMR technology are having an impact on metabonomics and these are also described. Finally, some recent applications of metabonomics are summarised including an improved understanding of normal physiological variation, the adverse effects of drugs and other xenobiotics, the impact of xenobiotic substances in environment pollution and the increasing use of metabonomics as a method for disease diagnosis.

Key words: NMR, LC-MS, metabolites, biomarkers, disease, diagnosis, toxicity, environment

CLC Number:

Q591

Lindon J C, Holmes E, Nicholson J K. Recent Developments and Applications of NMR-Based Metabonomics[J]. Chinese Journal of Magnetic Resonance, 2006, 23(1): 101-127.

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Recent Developments and Applications of NMR-Based Metabonomics

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