Chinese Journal of Magnetic Resonance

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APPLICATIONS OF HIGH RESOLUTION MAGIC ANGLE SPINNING NMR TO SOLID PHASE SYNTHESIS

HE Wen-yi1, YAO Nian-huan1, KIT S. Lam2,LIU Gang1*   

  1. 1.Chinese Academy of Medical Sciences & Peking Union College of Medicine, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, China;
     2.University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817, USA
  • Received:2003-03-20 Published:2003-06-05 Online:2003-06-05
  • About author:*Correspondence author:Liu Gang
  • Supported by:

    “863”项目(2001AA234061, 2001AA234021-04, 2002AA2Z343B).

Abstract:

General conditions that affect High Resolution Magic Angle Spinning NMR (HR/MAS) were studied in this paper including five resins, five solvents and t
emperature. A Solid phase synthesis of o-glycosylated Fmoc protected amino acid was then monitored. The results demonstrated that both resin and the solvent are critical factors in affection of acquisition of NMR singlets.

Key words: NMR, high resolution magic angle spinning NMR (HR/MAS), resin, solid phase synth

CLC Number: