Abstract:

Objective To determine the C-2 conformation of two pair of stereo-isomers of germacranolide type, which are scabertopin and isoscabertopin, isodeoxyel
ephantopin and deoxyelephantopin isolated from Elephantopus scaber. Methods The NOESY technique was used along with ¹H NMR，¹³C NMR and HMQC. Results The differences between the NOESY spectra of the two pairs of stereo-isomers were found. Conclusion The C-2 conformation of the two pairs of stereo-isomers from Elephantopus scaber can be determined through the NOESY technique.

Key words: NMR, NOESY, Elephantopus scaber, sesquiterpenoides, scabertopin, deoxyelephantopin