Chinese Journal of Magnetic Resonance

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NMR METHODS FOR DETERMINING THE CONFIGURATION OF  8-O-4′NEOLIGNANS

YUAN Zhong, LI Xian   

  1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, P.O. Box 28#, Shenyang 110016, China
  • Received:2003-03-31 Revised:2003-05-12 Published:2003-09-05 Online:2003-09-05

Abstract:

The NMR methods for determining the relative and absolute configurations of 8-O-4′Neolignans were reviewed. The relative stereochemistry between C-7
and C-8 should be in the erythro form if the coupling constant between the measured by 1H NMR is small (J=2.7~5.0 Hz). If the coupling constant me
asured is larger (J=6.0~8.6 Hz), the configuration is in the threo form. With the application of NOE difference spectroscopy, CD assay and Mosher's method, the absolute configuration can be determined.

Key words: NMR, 8-O-4′Neolignans, configuration, NOE difference spectroscopy, CD spectroscopy, Mosher's method

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