Chinese Journal of Magnetic Resonance ›› 2022, Vol. 39 ›› Issue (1): 33-42.doi: 10.11938/cjmr20212903
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Zhi-chao WANG1,Ji-lei ZHANG2,Yu ZHAO3,Ting HUA4,Guang-yu TANG4,Jian-qi LI1,*(
)
Received:2021-03-30
Published:2022-03-05
Online:2021-05-16
Contact:
Jian-qi LI
E-mail:jqli@phy.ecnu.edu.cn
CLC Number:
Zhi-chao WANG,Ji-lei ZHANG,Yu ZHAO,Ting HUA,Guang-yu TANG,Jian-qi LI. CEST Imaging of the Abdomen with Neural Network Fitting[J]. Chinese Journal of Magnetic Resonance, 2022, 39(1): 33-42.
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Table 1
The MRI parameters for simulation
| 质子池类别 | 生理参数类别 | 数值范围 |
| 自由水池 | 纵向弛豫率R1/s?1 | 0.5~1.3 |
| 自由水池 | 横向弛豫率R2/s?1 | 4~20 |
| 自由水池 | 化学位移 | δ ?1.6~1.6 |
| 半固态大分子MT池 | 质子浓度分数/% | 0~8 |
| 半固态大分子MT池 | 交换率/s?1 | 19~40 |
| 半固态大分子MT池 | 纵向弛豫率R1/s?1 | 1.1~1.35 |
| 半固态大分子MT池 | 横向弛豫率R2/s?1 | 8×104~1.5×105 |
Fig.1
Schematic of data processing. (a) Simulated background Z-spectra; (b) The acquired raw Z-spectrum, in which the red solid dots are inputted into the neural network to produce background reference Z-spectrum and water peak offset for correcting Z-spectrum later; (c) A simulated background Z-spectrum, in which the data marked as red solid dots are inputs for training and the complete Z-spectrum represented by blue line as well as the water peak offset are targets for training; (d) The feedforward neural network generated and applied; (e) The water peak offset and the background Z-spectrum (marked as bluish violet dashed curve) are obtained from the network and used to correct the raw Z-spectrum. The shaded part indicated by the arrow is the difference between bluish violet dashed curve and red solid curve, which is contributed from APT effect; (f) The APT map
Fig.2
The CEST imaging results of egg white. (a) T1 weighted image; (b) B0 map based on neural network; (c) The corrected Z-spectrum in egg white (red solid curve) and the background reference Z-spectrum (bluish violet dashed curve) obtained by neural network prediction, where the green arrow and yellow arrow indicate the positions of APT and NOE exchange, respectively; (d) MTRasym map of egg white; (e) APT map; (f) NOE map
Fig.3
Abdominal B0 maps and the corresponding CEST results of a healthy volunteer obtained by gradient recalled echo (GRE) sequence (the 2nd row) and neural network based method (the 3rd row). (a) The reference image while the CEST saturation radio frequency pulse was not applied; (b) & (e) B0 maps obtained by GRE sequence and neural network fitting, respectively; (c) & (f) MTRasym maps based on GRE sequence and neural network fitting, respectively; (d) & (g) The Z-spectrum analysis of tissue located in the orange circle in the left kidney based on GRE sequence and neural network fitting, respectively
Fig.4
The CEST results of a healthy volunteer obtained by the method based on neural network. (a) The corrected Z-spectrum (red solid curve) and background reference Z-spectrum (bluish violet dashed line), where the green arrow and yellow arrow indicate the positions APT and NOE, respectively; (b) APT map; (c) NOE map; (d) MTRasym map; (e) APTREX map; (f) NOEREX map
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