Structural Determination of Phencyclonate by 1D-HOHAHA  and 1D-NOESY NMR Spectroscopy

Abstract

Abstract:

Phencyclonate {2′-pheny-2′-cycloamyl-2′-hydroxyacetic-N-methly-3-azabiclo[3, 3, 1] nonane-9a-carboxylate} was synthesized and studied by 1D-HOHAHA and 1D-NOESY NMR spectroscopy employing frequency-selective radiofrequency pulses and pulsed field gradients. The results showed that all protons in the compound could be assigned by the combined use of the two techniques. Based on the results obtained from the 1D-NOESY experiment, the conformational property and C-9 configuration were elucidated as (1A).

Key words: NMR, 1D-NOESY, 1D-HOHAHA, stereochemistry, phencyclonate

CLC Number:

O641

Cite this article

LIU Li-Jun, MIAO Zhen-Chun, ZHONG Bo-Hua, LIU He, LIU Ke-Liang. Structural Determination of Phencyclonate by 1D-HOHAHA and 1D-NOESY NMR Spectroscopy[J]. Chinese Journal of Magnetic Resonance, 2006, 23(1): 23-29.

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