Abstract: ¹H and ¹³C NMR spectra of N (,N')-(di) tosyl macro-cyclic ether-bislactones (1-6), N,N'-dicarboxymethyl macrocyclic ether-bislactones and amine-bislactame (8-12) and 4'-dansylamino benzo crown ethers (13-16) etc. eighteen crown ethers were recorded and assigned by consideration of known substitute effects. The ¹H chemical shifts obtained indicate that the larger the crown ether, the larger the proton chemical shift for methylene b in Crown 1-6 and for methylene a, b, c in Crown 8-11. These shifts approach a limit when the number of macrocyclic atoms arrives at 21-24. Solvents show considerable effect on the ¹H chemical shifts of methylenes a, b, c in Crown 8-11 which increase with the solvent polarity, the order is as follows:CD₃COOD > PY-d₃ ≥ D₂O > CD₃OD > CD₃CD₂OD > DMF-d₇ > DMSO-d₆.

Key words: Crown ether derivatives of EDTA, NMR