Study on the Automatic Accumulation-thawing Device of Hyperpolarized 129Xe

doi:10.11938/cjmr20222998

Abstract

Abstract:

Due to the detection sensitivity provided by the high nuclear spin polarization, hyperpolarized ¹²⁹Xe has been employed in animal and human magnetic resonance imaging (MRI). However, during the accumulation-thawing process of hyperpolarized ¹²⁹Xe, multiple factors lead to the relaxation of spin polarization and would hinder the wider application of ¹²⁹Xe. In this research, the spin relaxation mechanism of hyperpolarized ¹²⁹Xe during the accumulation-thawing process is investigated by both theoretical model analysis and experimental measurements. Meanwhile, the stability of the homebuilt device for the accumulation-thawing is measured. Our results demonstrate that the thawing mode and the cold trap material significantly affect the polarization loss; the automatic device is very stable during long-term operation and shows a high degree of automation, resulting in a polarization recovery ratio of 85.6% ± 4.7%. This research greatly helps to improve the efficiency of hyperpolarized ¹²⁹Xe in animal and human MRI.

Key words: magnetic resonance imaging, hyperpolarized ¹²⁹Xe gas, automatic accumulation-thawing device, recovery ratios of polarization

CLC Number:

O482.53

Xiao-ming CHEN, Xiu-chao ZHAO, Xian-ping SUN, Jun-shuai XIE, Hai-dong LI, Ye-qing HAN, Xiao-ling LIU, Qi CHEN, Xin ZHOU. Study on the Automatic Accumulation-thawing Device of Hyperpolarized ¹²⁹Xe[J]. Chinese Journal of Magnetic Resonance, 2022, 39(3): 316-326.

Figures/Tables 9

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References 25

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Study on the Automatic Accumulation-thawing Device of Hyperpolarized ¹²⁹Xe

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