Evaluation of the Influence of Data Sampling Schemes on Neural Diffusion Models

doi:10.11938/cjmr20202870

Abstract

Abstract:

The joint application of multiple diffusion models on single sampled dataset is becoming a hot topic in clinical research. This study investigated the influence of the three data sampling schemes on the quantification of neural diffusion models. The three sampling schemes compared were QGrid, Free and MDDW on the Siemens scanners. The diffusion models involved were diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), neurite orientation dispersion and density imaging (NODDI) and mean apparent propagator (MAP) models. It was demonstrated that the results of NODDI and MAP were sensitive to the sampling schemes and the set of maximum b-value, while that of DTI and DKI were comparatively not sensitive to varying configurations. It was also shown that QGrid and Free schemes provided more consistent results. Thus the sampling scheme should be carefully selected in multi-center studies and studies with large sample size. QGrid and Free schemes are recommended for their advantages demonstrated in this study.

Key words: magnetic resonance imaging, data sampling scheme, diffusion model, diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), neurite orientation dispersion and density imaging (NODDI), mean apparent propagator (MAP)

CLC Number:

O482.53

Min-xiong ZHOU, Hui-ting ZHANG, Yi-da WANG, Guang YANG, Xu-feng YAO, An-kang GAO, Jing-liang CHENG, Jie BAI, Xu YAN. Evaluation of the Influence of Data Sampling Schemes on Neural Diffusion Models[J]. Chinese Journal of Magnetic Resonance, 2022, 39(2): 220-229.

Figures/Tables 6

Table 1

Fig.1

Table 2

Fig.2

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模型	参数	全名（英文/中文）	物理含义
DTI	FA	fractional anisotropy各向异性分数	反映扩散系数在空间上分布不均匀的程度.
DTI	MD\AD\RD	mean\axial\radial diffusivity平均\轴向\径向扩散系数	反映平均、轴向（神经纤维方向）和垂直于轴向平面的扩散速率.

DKI	MD\AD\RD	mean\axial\radial diffusivity 平均\轴向\径向扩散系数	与DTI的MD\AD\RD参数类似，但为校正后的扩散速率.
DKI	MK\AK\RK	mean\axial\radial kurtosis 平均\轴向\径向扩散峰度	反映平均、轴向（神经纤维方向）和垂直于轴向平面的扩散偏离正态分布的程度，与扩散受限和多组织成分混杂有关.

NODDI	ICVF	intra-cellular volume fraction 细胞内容积比	为细胞内信号占总扩散信号的比例，与神经突密度相关.
	ISOVF	isotropic volume fraction 各向同性容积比	为各向同性信号占总扩散信号的比例，通常反映脑脊液信号
	ODI	orientation dispersion index 方向分散指数	量化神经轴突方向角度的不一致性，其值在单方向的神经组织中趋近于0，在各向同性组织趋近于1.

MAP	RTOP	return-to-the-origin probability 返回原点概率	水分子在扩散过程中不发生净位移的概率，反映扩散受限程度.
	MSD	mean squared displacement 平均平方位移	单位时间内水分子的均方位移，反映扩散速率，与DTI/DKI的MD参数接近.
	QIV	Q space inverse variance Q空间逆方差	Q空间信号几何平均值的逆方差
	NG	no-Gaussianity 非高斯性	含义与DKI中的MK接近，反映扩散偏离正态分布的程度.

	DTI		DKI		MAP				NODDI
	FA	MD	MD	MK	MSD	NG	QIV	RTOP	ICVF	ISOVF	ODI
灰质	0.06	0.04	0.01	0.05	0.09	0.04	0.08	0.11	0.07	0.47	0.01
白质	0.02	0.01	0.03	0.04	0.06	0.08	0.09	0.03	0.01	0.11	0.04

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